Diagnostic value of brain MRI and 18F‐FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson’s disease
Identifieur interne : 000E22 ( Main/Exploration ); précédent : 000E21; suivant : 000E23Diagnostic value of brain MRI and 18F‐FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson’s disease
Auteurs : K. Kwon ; C. G. Choi ; J. S. Kim [Corée du Sud] ; M. C. Lee ; S. J. ChungSource :
- European Journal of Neurology [ 1351-5101 ] ; 2008-10.
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Abstract
Background and purpose: Differentiation between parkinsonian type multiple system atrophy (MSA‐P) and Parkinson’s disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) and 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG PET) in differentiating MSA‐P from PD. Methods: Twenty‐four patients with MSA‐P (16 probable and 8 possible) and eight patients with PD were included in this study. Results: For analysis using the putaminal findings, the sensitivities were 58.3% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, and 79.2% by statistical parametric mapping (SPM) analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Using the putaminal findings, visual analysis of 18F‐FDG PET had a higher sensitivity compared with brain MRI (P = 0.004) and SPM analysis of 18F‐FDG PET revealed a tendency towards higher sensitivity compared with brain MRI (P = 0.063). For analysis using both putaminal and infratentorial findings, the sensitivities were 79.2% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, 95.8% by SPM analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Conclusion: Both brain MRI and 18F‐FDG PET showed diagnostic usefulness in differentiating MSA‐P from PD, with 18F‐FDG PET being more sensitive than brain MRI.
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DOI: 10.1111/j.1468-1331.2008.02235.x
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Chung</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1468-1331.2008.02235.x</idno><idno type="url">https://api.istex.fr/document/C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001E25</idno><idno type="wicri:Area/Main/Curation">001B39</idno><idno type="wicri:Area/Main/Exploration">000E22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Diagnostic value of brain MRI and 18F‐FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson’s disease</title><author><name sortKey="Kwon, K" sort="Kwon, K" uniqKey="Kwon K" first="K." last="Kwon">K. Kwon</name><affiliation><wicri:noCountry code="subField">Center for Parkinsonism and Other Movement Disorders</wicri:noCountry></affiliation></author><author><name sortKey="Choi, C G" sort="Choi, C G" uniqKey="Choi C" first="C. G." last="Choi">C. G. Choi</name><affiliation><wicri:noCountry code="no comma">Departments of Radiology</wicri:noCountry></affiliation></author><author><name sortKey="Kim, J S" sort="Kim, J S" uniqKey="Kim J" first="J. S." last="Kim">J. S. Kim</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, M C" sort="Lee, M C" uniqKey="Lee M" first="M. C." last="Lee">M. C. Lee</name><affiliation><wicri:noCountry code="subField">Center for Parkinsonism and Other Movement Disorders</wicri:noCountry></affiliation></author><author><name sortKey="Chung, S J" sort="Chung, S J" uniqKey="Chung S" first="S. J." last="Chung">S. J. Chung</name><affiliation><wicri:noCountry code="subField">Center for Parkinsonism and Other Movement Disorders</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-10">2008-10</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1043">1043</biblScope><biblScope unit="page" to="1049">1049</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">C524F8DED52BBB1DD6DC0A6A462FE3CDEE0DEFB6</idno><idno type="DOI">10.1111/j.1468-1331.2008.02235.x</idno><idno type="ArticleID">ENE2235</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>18F‐fluorodeoxyglucose positron emission tomography</term><term>Parkinson’s disease</term><term>magnetic resonance imaging</term><term>parkinsonian type multiple system atrophy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background and purpose: Differentiation between parkinsonian type multiple system atrophy (MSA‐P) and Parkinson’s disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) and 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG PET) in differentiating MSA‐P from PD. Methods: Twenty‐four patients with MSA‐P (16 probable and 8 possible) and eight patients with PD were included in this study. Results: For analysis using the putaminal findings, the sensitivities were 58.3% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, and 79.2% by statistical parametric mapping (SPM) analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Using the putaminal findings, visual analysis of 18F‐FDG PET had a higher sensitivity compared with brain MRI (P = 0.004) and SPM analysis of 18F‐FDG PET revealed a tendency towards higher sensitivity compared with brain MRI (P = 0.063). For analysis using both putaminal and infratentorial findings, the sensitivities were 79.2% by visual analysis of brain MRI, 95.8% by visual analysis of 18F‐FDG PET, 95.8% by SPM analysis of 18F‐FDG PET in differentiating MSA‐P from PD; the specificity was 100% for each analysis. Conclusion: Both brain MRI and 18F‐FDG PET showed diagnostic usefulness in differentiating MSA‐P from PD, with 18F‐FDG PET being more sensitive than brain MRI.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><noCountry><name sortKey="Choi, C G" sort="Choi, C G" uniqKey="Choi C" first="C. G." last="Choi">C. G. Choi</name><name sortKey="Chung, S J" sort="Chung, S J" uniqKey="Chung S" first="S. J." last="Chung">S. J. Chung</name><name sortKey="Kwon, K" sort="Kwon, K" uniqKey="Kwon K" first="K." last="Kwon">K. Kwon</name><name sortKey="Lee, M C" sort="Lee, M C" uniqKey="Lee M" first="M. C." last="Lee">M. C. Lee</name></noCountry><country name="Corée du Sud"><noRegion><name sortKey="Kim, J S" sort="Kim, J S" uniqKey="Kim J" first="J. S." last="Kim">J. S. Kim</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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